Journal: Journal of Biomedical Science
Article Title: Diagnosis of transition zone prostate cancer by multiparametric MRI: added value of MR spectroscopic imaging with sLASER volume selection
doi: 10.1186/s12929-021-00750-6
Figure Lengend Snippet: Results of support vector machine analysis to separate tumor aggressiveness classes. Left side: ROC curves of the six RBF-SVM models for low-risk vs high-risk cancer, low-risk vs intermediate-risk cancer and intermediate-risk vs high-risk cancer. A leave-one-out cross-validation technique was used for the combined ADC and K trans (dashed line) and all the combined ADC, K trans and metabolite ratios (solid line) with a significant difference between the two groups ( p < 0.05). Right side: bar charts of AUC values, sensitivity and specificity of the corresponding RBF-SVM models. McNemar test was used for pairwise comparison of sensitivity and specificities of models and Delong test was calculated for pairwise comparison of AUC of models. ** p < 0.01 and * p < 0.05
Article Snippet: We developed a machine learning platform for mp-MRI including support vector machine (SVM) classifications with a radial basis function kernel (RBF-SVM) and area under receiver operator characteristic (ROC) analyses using an in-house Matlab routine to evaluate the diagnostic performance of models with different parametric combinations: T2WI + DWI, T2WI + DWI + DCE, T2WI + DWI + MRSI, and T2WI + DWI + DCE + MRSI.
Techniques: Plasmid Preparation, Biomarker Discovery, Comparison